• Laser Hair Removal
• General Information
• Hair Removal Methods

MEDICAL TREATMENT

Oral Contraceptives

Ovarian hyperandrogenisms, polycystic ovary syndrome or idiopathic syndromes with or without association to anti-androgens.
They decrease LH levels and increase SBG levels, decreasing free SBG.
As with some progestagens they can have androgenic activity and must be used with anti-androgenic component or with nil activity.
Results become apparent after 6 to 12 months.
Gynaecological follow-up required.

Corticoids

Congenital, suprarenal hyperplasia as they suppress ACTH secretion
Dexamethasone 0.5-1 mg at night
A cortisol concentration of 2mg/dl in the morning is required

Cyproterone Acetate

It is the most widely used substance
It competes with testosterone in the androgenic receptor and decreases 5-alpha-reductase activity
Inhibits LH secretion by way of its progestagen action which in turn decreases androgen synthesis
Administration of 50 to 100 mg per day should be associated with contraception, given that this substance is a progestagen that would alter the cycle and could cause feminization of the male foetus
In postmenopausal women it can be administered on a continued basis without oral contraceptives
A preparation containing a 2mg dose is available, which can be sufficient in mild cases although with a slower action. This medication contains estrogens and can be used as a contraceptive (Diane 35)
Side-effects: Tiredness, decreased libido, weight gain and high blood pressure.

OTHER ANTIANDROGENS

Spironolactone

It is an aldosterone antagonist with antiandrogenic activity thus competing with the dehydrotestosterone receptor. It also blocks steroidogenesis at the level of the gonads due to the action cytochrome P450.
It must be accompanied by contraception
50 to 200 mg per day for at least six months.
Side effects are frequent but mild and include decreased libido, breast tenderness, hyperpotassemia, sleepiness, headache, gastrointestinal alterations
Useful in polycystic ovary syndrome and idiopathic hirsutism

Flutamide

Antiandrogen that competes with DHT receptor, decreasing DHEAS.
More effective than spironolactone
Useful in hirsutism and alopecia
Must be accompanied by contraception
250 mg every 12 hours for at least nine months
Side effects: insomnia, cholestasis, decreased libido, breast tenderness, hypertransaminasemia, xerosis.

OTHER TREATMENTS

Finasteride

It appears to reduce hair growth at a dose of 5 mg

Weight Loss

Antidiabetics In Polycystic Ovary Syndrome